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pentobarbital will lower the extent or impact of osilodrostat by influencing hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital decreases amounts of panobinostat by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Powerful CYP3A4 inducers can cut down panobinostat degrees by ~70% and result in therapy failure.pentobarb

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